What do swollen lymph nodes mean in neck

Almost everyone will experience a swollen lymph node at some point. That’s because these structures are designed to filter germs and other impurities from the body.

Lymph nodes become swollen as they trap viruses, harmful bacteria and damaged cells, then attempt to destroy them with lymphocytes, the white blood cells that fight off infection.

But swollen lymph nodes can also be a sign of cancer, including a type of blood cancer called lymphoma. So, when are swollen lymph nodes just a sign of infection, as opposed to a symptom of lymphoma? We checked in with lymphoma and myeloma specialist Felipe Samaniego, M.D.

How often do swollen lymph nodes appear as the first sign of lymphoma in undiagnosed patients?

That’s kind of hard to say. By the time we see most patients here at MD Anderson, they’ve already been diagnosed elsewhere or been told there’s a strong possibility that whatever it is that they have is cancer.

That being said, in the greater community, swollen lymph nodes among undiagnosed patients tend to fall into one of two categories:

  1. Lymph nodes that patients notice or that a doctor sees or feels during a physical exam
  2. Lymph nodes that are found during an MRI or a CT scan because the patient is complaining of something else, such as chest pain or a lump in their breast

What are the most common places in the body where swollen lymph nodes occur as a sign of lymphoma?

Most will be in the neck, because the mouth and throat — or oropharyngeal tract — are the main gateway for things to get inside our bodies. So, we need to have a good defense system there.

But patients can find swollen lymph nodes in other places, too — especially where they lie close to the skin’s surface, like the groin area (where the leg meets the trunk) and the axilla, or armpit.

Lymphoma is actually detected pretty frequently during mammograms, because the field of view also covers the armpit, so it reveals swollen lymph nodes in that area.

Occasionally, patients may develop swollen lymph nodes all over their bodies, but this is relatively rare.

Is there a way to tell the difference between cancerous swollen lymph nodes and non-cancerous ones?

Anyone who’s really concerned about a swollen lymph node should go see their doctor. But here are some general guidelines:

  • Size: Lymph nodes are made to change in size because they’re doing a job. They grow larger as the number of cells caught inside of them increases and shrink back down to normal as that number drops. But the normal size of an average lymph node is under 1.5 centimeters, or about ¾ of an inch or smaller. So, if something is larger than that or growing continuously, it needs to be checked out.
  • Age: Infections are a frequent cause of swollen lymph nodes among young people. So, if you’re a teen or a college student, my first thought would be something like strep throat or mononucleosis. Cancer is more likely in older people, though I’d still want to rule out an infection first. Even among older groups, probably less than half the people who have swollen lymph nodes will have them because of cancer.
  • Consistency: Press the tip of your nose with your finger and you’ll have a pretty good idea of what a typical lymph node should feel like. Tumors tend to be harder and more solid, like what you’ll feel if you push on your chin with your finger.
  • Sensitivity: Some people think cancer always hurts, but that’s not true. Tenderness tends to be a sign of an infectious process, because the immune system has been challenged. But lymph nodes that are swollen due to lymphoma are usually not painful.

What are other common symptoms of lymphoma?

In lymphoma’s earliest stages, patients often report itchy, inflamed skin or unexplained rashes. In more advanced cases, where patients have large tumors, we start seeing weight loss, fevers, night sweats, and fatigue. Some experience painful muscle aches after drinking alcohol, too, though that is fairly unusual.

When should someone see their doctor about a swollen lymph node?

Swollen lymph nodes usually just mean your body is working the way it’s supposed to. But if a swollen lymph node keeps getting bigger or doesn’t resolve on its own within two weeks, get it checked out.

Request an appointment at MD Anderson online or by calling 1-877-632-6789.

Medically Reviewed by Sabrina Felson, MD on August 22, 2022

When you have swollen lymph nodes, your first thought shouldn't be, "I have cancer." They're much more likely to be caused by infections or a disease that affects your immune system, and they will often clear up as your body heals.

But sometimes, cancer cells will travel through your bloodstream and end up in your lymph nodes, or even start there.

Your doctor can help you figure out what's causing the changes in your body.

Why Lymph Nodes Swell

There are more than 600 small, kidney bean-shaped lymph nodes in clusters throughout your body -- under your neck, in your armpits and groin, and in the middle of your chest and belly. These store immune cells and act as filters to remove germs, dead and damaged cells, and other waste from your body.

Swollen lymph nodes are a sign that they're working hard. More immune cells may be going there, and more waste could be building up. Swelling usually signals an infection of some kind, but it could also be from a condition like rheumatoid arthritis or lupus, or rarely, cancer.

Often, swollen lymph nodes will be close to where the problem is. When you have strep throat, lymph nodes in your neck may swell. Shingles will cause swollen lymph nodes in the area where the rash breaks out.Women who have breast cancer may get swollen lymph nodes in their armpit.

When several areas of lymph nodes are swollen, that suggests the problem is throughout your body. It could be something like chickenpox, HIV, or a cancer such as leukemia or lymphoma.

When to See a Doctor

You'll often have a good idea why a lymph node is swollen -- you've got a cold, your tooth is infected, or you have a cut that isn't healing well. If you can't come up with an explanation, it may be time to get checked out.

Lymph nodes that are around 1/2 inch or bigger aren't normal. They shouldn't feel hard or rubbery, and you should be able to move them. The skin over them should not be red, irritated, or warm. And the swelling should go away within a couple of weeks. You should see your doctor if your lymph nodes appear abnormal."

Other symptoms are also a reason to make an appointment:

  • Trouble breathing or swallowing
  • Night sweats
  • Fever that doesn't break
  • Losing weight without trying to
  • Fatigue

Getting a Diagnosis

Your doctor will probably try to rule out reasons other than cancer first. They'll do a physical exam and ask about things that have happened, like if you've:

  • Been scratched by a cat
  • Been bitten by a tick
  • Eaten undercooked meat
  • Had risky sex or injected street drugs
  • Traveled to certain places or areas

They'll want to know what medications you're taking and other symptoms you have.

Swollen nodes that are close to your collarbone or the lower part of your neck when you're over 40 are more likely to be cancer. On the right side, related to the lungs and esophagus; on the left, organs in your belly. Swollen lymph nodes in your armpit when you don't have a rash or sores on your arm can also be suspect.

If your doctor thinks your swollen lymph nodes could be cancer, tests and imaging can confirm the diagnosis or point to something else. Based on where the cancer might be, you could get a chest X-ray, an ultrasound, a CT scan, or an MRI. A scan called FDG-PET, which stands for fluorodeoxyglucose with positron emission tomography, can help find lymphoma and other cancers. And you'll probably get a biopsy. They'll take either a sample of cells from a node, typically using a needle, or remove a whole node. The sample gets sent to a lab so a specialist can check it with a microscope for cancer.

Otherwise, you'll usually start with a complete blood count (CBC) to get a picture of your general health as well as more detailed information about your white blood cells, which fight infection. Depending on your other symptoms and your history, your doctor may want additional blood tests or x-rays, too.

If these tests don't show another cause and the swollen nodes don't go away in 3-4 weeks, your doctor will probably do a biopsy. Since the swelling will often go away or another cause will be found while you're waiting to do a biopsy, the delay prevents people from getting procedures they don't need. And even if it is cancer, you should still be able to treat it effectively.

When you have swollen lymph nodes throughout your body, your doctor will ask for a CBC, a chest X-ray, and an HIV test. If these are normal, you might get other tests, perhaps for tuberculosis or syphilis, an antinuclear antibody test (which checks your immune system), or a heterophile test (for the Epstein-Barr virus). The next step is a biopsy of the most abnormal node.

What Does Cancer in a Lymph Node Mean?

Cancer in your lymph nodes may point to lymphoma or another blood cancer, or may be a cancer that has spread from another site. 

Based on the source of the cancer cells and how far away that is from the swollen nodes, your doctor will recommend a treatment plan. It could include surgery, radiation, or chemotherapy, or a combination of treatments.

When should I worry about swollen lymph nodes in neck?

See your doctor if you're concerned or if your swollen lymph nodes: Have appeared for no apparent reason. Continue to enlarge or have been present for two to four weeks. Feel hard or rubbery, or don't move when you push on them.

What causes swollen lymph nodes in the neck?

Lymph nodes produce immune cells to help fight infection. They also filter the lymph fluid and remove foreign material, such as bacteria and cancer cells. They can become swollen from inflammatory conditions, an abscess, cancer, and most commonly from infection.

Are swollen lymph nodes in neck serious?

Swollen lymph nodes can be a literal pain in the neck. But more often than not, minor infection or illness is the cause. They should go away as soon as your condition clears up. If you have swollen lymph nodes that don't go away or seem to grow over time, see your healthcare provider.

What to do if your lymph nodes in your neck are swollen?

If your swollen lymph nodes are tender or painful, you might get some relief by doing the following:.
Apply a warm compress. Apply a warm, wet compress, such as a washcloth dipped in hot water and wrung out, to the affected area..
Take an over-the-counter pain reliever. ... .
Get adequate rest..